Publications | hwanglab

2015 - Current

65. J. Jeong, K. Noh, S. Hur#, J.K. Chung#, and Y. Hwang#: "The roles matrix stiffness in mechanotransduction of pterygium fibroblast phenotypes and its disease progression" (in preparation) (#denotes co-corresponding authors)

64. J. Jeong, K. Noh, S. Hur#, J.K. Chung#, and Y. Hwang#: "Mechanosensation mediates pterygium epithelial cell phenotypes and its disease progression" (in preparation) (#denotes co-corresponding authors)

63. J. Kim*, S. Hur*, L. Anggradita*, M. J. Ban#, and Y. Hwang#: "Phosphorylated focal adhesion kinase by mild reduction of cell surface proteins inhibits integrin α5β1-dependent patient-derived cancer cell migration and invasion" (in preparation) (#denotes co-corresponding authors)

62. M. Kim*, S. Hur*, Y. Kim, J. Kim, Y. Kim, J. H. Lee#, Y. Hwang#: "Unveiling the focal adhesion-lysyl oxidase axis: Inhibition of chondrocyte dedifferentiation explored through traction force microscopy" (in preparation) (#denotes co-corresponding authors)

61. S. Hur*, Y. Kim*, J. Kim, J. H. Lee#, Y. Kim#, and Y. Hwang#: "Lamin A and Cellular Forces Interplay in Chondrocyte Dedifferentiation: Steering Fibrochondrocyte Phenotypic Regulation" (in preparation) (#denotes co-corresponding authors)

60. L. Anggradita*, S. Hur*, J. Kim, M. J. Ban#, and Y. Hwang#: "A mild reduction of the cell surface proteins inhibits adipogenic potential of preadipocytes via ITGB1/FAK-induced RhoA/ROCK2 signaling integrin α5β1-dependent tongue cancer cell migration and invasion" (in preparation) (#denotes co-corresponding authors)

59. L. Anggradita*, J. Kim*, M. Kim*, J. Son, M. Farhan, J. H. Park, S. Hur#, M. J. Ban#, and Y. Hwang#: "Inhibition of ITGB1/FAK Pathway and Cellular Mechanics in Tongue Cancer Epithelial Cells by Artemisinin: Targeting Mechanotransduction for Anti-Cancer Therapy" (in preparation) (#denotes co-corresponding authors)

58. J. Subitsha, J. Jeong, S. Hur, G. Augustin, M. Kim, Y. Shin, Y. Kim, J. Son, J. Lee#, and Y. Hwang#: "Enhancing Tendon-derived Stem Cell Dynamics: Role of Polydeoxyribonucleotide in Proliferation and Migration via Adenosine A2A Receptor-mediated Cellular Forces" (in preparation) (#denotes co-corresponding authors)

57. J. Jeong*, S. Hur*, K. Cho#, and Y. Hwang#: "A mild reduction of the cell surface proteins determines adipogenic potential of preadipocytes via ITGB1/FAK-induced RhoA/ROCK2 signaling" (in preparation) (#denotes co-corresponding authors)

56. Rachel H. Koh, Junhee Kim, Jeong-Uk Kim, Seunghyun L. Kim, Arun Kumar, Joohyun Kim, Ji Hoon Jeong, Yongsung Hwang, Jong Woo Bae, and Nathaniel Suk-Yeon Hwang: "Whitlockite-mediated hypertrophic cartilage formation promotes regeneration of osteochondral interface and subchondral bone in rabbit osteochondral defect model" (revision submitted, Bioactive Materials)

55. George Augustine, Ji Hoon Jeong, Min-Kyu Kim, Sung Sik Hur, Joon Ho Lee#, and Yongsung Hwang#: "Stem Cell-Based Therapies and Tissue Engineering Innovations for Tendinopathy: A Comprehensive Review of Current Strategies and Future Directions" Advanced Therapeutics, 2024. (Link) (#denotes co-corresponding authors)

54. M. Subramaniam*, J. Bae*, J. Son*, L. Anggradita, M. Kim, M. Lee, S. Jang, K. Choi, J. Lee, S. Nam#, and Y. Hwang#: "Floating electrode-dielectric barrier discharge-based plasma promotes skin regeneration in a full-thickness skin defect mouse model" Biomedical Engineering Letters, 2024,14(3):605-616. (Link) (#denotes co-corresponding authors)

53. P. Sittipo*, L. Anggradita*, H. Kim*, C. Lee, N. S. Hwang#, Y. Lee#, and Y. Hwang#: "Cell surface modification-mediated primary intestinal epithelial cell culture platforms for assessing host-microbiota interactions" (#denotes co-corresponding authors) Biomaterials Research, 2024, 28:0004. (Link)

- (BRIC Bio News)(순천향대학교 #1)(순천향대학교#2)(Newspaper#1)(Newspaper#2)(한빛사)

52. Danielle Vahala, Sebastian E. Amos, Marta Sacchi, Bram G. Soliman, Matt S. Hepburn, Alireza Mowla, Jiayue Li, Ji Hoon Jeong, Chrissie Astell, Yongsung Hwang, Brendan F. Kennedy, Khoon S. Lim, and Yu Suk Choi: "3D Volumetric Mechanosensation of Breast Cancer Spheroids in a Linear Stiffness Gradient GelAGE" Advanced Healthcare Materials, 2023, 2301506. (Link)

51. J. Jeong*, K. Nam*, J. Kim, K. Noh, S. Hur, Y. Kim, M. Hong, J. Chung, J. Park, J. Lee, Y. Son, J. Lee, S. Kim#, and Y. Hwang#: Self-organized insulin-producing β-cells differentiated from human omentum-derived stem cells and their in vivo therapeutic potential" (#denotes co-corresponding authors) Biomaterials Research, 2023, 27:82. (Link)

- (BRIC Bio News)(순천향대학교)(Newspaper#1)(Newspaper#2)(한빛사)(헬스조선 인터뷰)

50. (Book chapter) J. Jeong, J. Kim, J. H. Park, and Y. Hwang: "Organoid-based Disease Modeling and Cell Therapy" Regenerative Medicine 5th edition (Chapter 59), Koonja Publishing Inc., May 20th, 2023, ISBN# 9791170680062. (Link)

49. S. Lee*, J. Kim*, S. Yi, H. Yeo, Y. Lee, Y. Hwang#, and J. Lee#: "Systematic evaluation of antibiotic activity of a cefazolin-loaded scaffold with varying 3D printing temperatures and its application in treating osteomyelitis" Journal of Industrial Engineering and Chemistry, 2023, 124, 539-549. (#denotes co-corresponding authors) (Link)

48. E. Chung*, J. Son*,Y. Eun, N. Yang, J. Kim, S. Lee, Y. Choi, N. Heo, J. Rhee, S. Lee, Y. Hwang#, and J. Kim#: "A novel, home-use, low-level light therapy device for the treatment of acne vulgaris: A single-arm, prospective clinical study" Dermatologic Therapy, 2023, Vol 2023, 1-11. (Article ID: 8846620) (#denotes co-corresponding authors) (Link)

47. H.K. Kim, H.Kim, J.Y. Kim, M.J. Ban, J. Son, Y. Hwang, and S. Cho: "Immediate and Late Effects of Pulse Widths and Cycles on Bipolar, Gated Radiofrequency-induced Tissue Reactions in In Vivo Rat Skin" Clinical, Cosmetic and Investigation Dermatology, 2023, 16, 721-729. (Link)

46. O. Levana*, J. Jeong*, S. Hur, W. Seo, M. Lee, K.M. Noh, S. Hong, J.H. Park, J.H. Lee#, C. Choi#, and Y. Hwang#: "Development of nanoclay-based nanocomposite surfaces with antibacterial properties for potential biomedical applications" (#denotes co-corresponding authors) Journal of Industrial Engineering and Chemistry, 2023, 120, 448-459. (Link)

45. J. Jeong*, S. Hur*, S. Lobionda*, S. Chaycham, J.S. Oh#, Y.K. Lee#, and Y. Hwang#: "Heparin-mimicking polymer-based hydrogel matrix regulates macrophage polarization by controlling cell adhesion" (#denotes co-corresponding authors) Biochemical and Biophysical Research Communications, 2023, 642, 154-161. (Link)

44. E. Lloyd, M. Hepburn, J. Li, A. Mowla, Y. Hwang, Y. Choi, M. Grounds, and B. Kennedy: "Three-dimensional mechanical characterization of murine skeletal muscle using quantitative micro-elastography" Biomedical Optics Express, 2022, 13(11), 5879-5899. (Link)

43. I. Chin, S. Amos, J. Jeong, L. Hool, Y. Hwang, and Y. Choi: "Volume adaptation of neonatal cardiomyocyte spheroids in 3D stiffness gradient GelMA" Journal of Biomedical Materials Research: Part A, 2022;1-13. (Link)

42. I. Chin, S. Amos, J. Jeong, L. Hool, Y. Hwang, and Y. Choi: "Mechanosensation mediates volume adaptation of cardiac cells and spheroids in 3D" Materials Today Bio, 2022, 16, 100391. (Link)

41. O. Levana*, S. Hong*, S. Kim, J. Jeong, S. Hur, J. Lee, K. Kwon#, and Y. Hwang#: "A novel strategy for creating antibacterial surface using a highly efficient electrospray-based deposition" (#denotes co-corresponding authors) International Journal of Molecular Sciences, 2022, 23(1), 513. (Link)

40. K. Ahn, E. Park, C. Choi, H. Cha, Y. Hwang# and S. Nam#: “Hyaluronic Acid Treatment Improves Healing of the Tenorrhaphy Site by Suppressing Adhesion through Extracellular Matrix Remodeling in a Rat Model” (#denotes co-corresponding authors) Polymers, 2021, 13(6), 928 (Link)

39. J. Kim, S. Park, H. Choi, Y. Hwang, M. Ban, and J. Park: “Cotton ball self-retraction technique: a novel surgical method used during microflap dissection” Laryngoscope, 131(9): E2553–E2557, 2021. (Link)

38. H. Kim, J. Jeong, M. Fendereski, H. Lee, D. Kang, Y. Kim, N. Pham, S. Hur, J. Amirian, N. Suh, N. Hwang, S. Ryu, J. Yoon#, and Y. Hwang:#: "Heparin-mimicking polymer-based in vitro platform to recapitulate in vivo muscle atrophy phenotypes" (#denotes co-corresponding authors) International Journal of Molecular Sciences, 2021, 22(5), 2488. (Link)

37. H. Kim, L. Anggradita, S. Lee, S. Hur, N. S. Hwang, S. Nam#, and Y. Hwang#: “Ameliorating fibrotic phenotypes of keloid skin-derived dermal fibroblasts through a EGF signaling pathway” International Journal of Molecular Sciences, 2021, 22(4), 2198. (Link) (#denotes co-corresponding authors)

36. S. Hong, S. Oh, D. Choi, Y. Hwang#, and S. Kim#: "Self-organized Liver Microtissue on a Bio-functional Surface: the Role of Human Adipose-derived Stromal Cells in Hepatic Function", International Journal of Molecular Sciences, 2020, 21(13), 4605. (#denotes co-corresponding authors) (Link)

35. S. Kim, J. Nam, M. Lee, Y. Hwang, and E. Park: "Effects on wound healing of human induced pluripotent stem cell-derived cells similar to endothelial colony-forming cells", Journal of Wound Management and Research, 2020, 16(1), 3-12. (Link)

34. S. Hur, J Jeong, M. Ban, J. Park, J Yoon#, and Y. Hwang#: "Traction force microscopy for understanding cellular mechanotransduction", BMB Reports, 2020, 53(2), 74-81. (#denotes co-corresponding authors) (Link)

33. M. Hepburn, P. Wijesinghe, L, Major, J. Li, A. Mowla, C. Astell, H. Park, Y. Hwang, Y. Choi, and B. Kennedy: "Three-dimensional imaging of cell and extracellular matrix elasticity using quantitative micro-elastography", Biomedical Optics Express, 2020, 11(2), 867-884. (Link)

32. C. Kim, J. Young, A. Holle, K. Jeong, L. Major, J. Jeong, Z. Aman, D. Han, Y. Hwang, J. Spatz, Y. Choi: "Stem cell mechanosensation on gelatin methacrylol (GelMA) stiffness gradient hydrogels", Annals of Biomedical Engineering, 2020, 48, 893-902. (Link)

31. L. Major, A. Holle, J. Young, M. Hepburn, K. Jeong, I. Chin, R. Sanderson, J. Jeong, Z. Aman, B. Kennedy, D. Han, Y. Hwang, H. Park, K. Guan, J. Spatz, Y. Choi: "Volume adaptation controls stem cell mechanotransduction", ACS Applied Materials and Interfaces, 2019, 11, 45520-45530 (Link)

30. D. Han, C. Ahn, J. Lee, Y. Hwang, J. Kim, K. Park, J. Lee, and K. Son: "Optimization of electrospun poly(caprolactone) fiber diameter for vascular scaffolds to maximize smooth muscle cell infiltration and phenotype modulation", Polymers, 2019, 11(4), 643 (Link)

29. J. Sah, N. Hao, Y. Kim, T. Eigler, E. Tzahor, S. Kim#, Y. Hwang#, and J. Yoon#: “MBP-FGF2-immobilized matrix maintains the self-renewal and myogenic differentiation potential of skeletal muscle stem cells”, International Journal of Stem Cells, 2019, 12(2), 360-366. (#denotes co-corresponding authors) (Link)

28. H. Kim, Y. Kim, J. Park, N.S. Hwang, Y. Lee, and Y. Hwang: "Recent Advances in Engineered Stem Cell-derived Cell Sheets for Tissue Regeneration", Polymers, 2019, 11(2), 209. (Link)

27. T. Ha, H. Kang, T, Kim, J. Kwon, H. Kim, A. Ryu, H. Jeon, J. Han, H. Broxmeyer, Y. Hwang#, Y. Lee#, and M. Lee#: “MiR-9 controls chemotactic activity of cord blood CD34+ cells by repressing CXCR4 expression” International Journal of Stem Cell, 2018, 11(2), 187-195. (#denotes co-corresponding authors) (Link)

26. (Book chapter) H. Kim, Y. Kim, M. Fendereski, N. S. Hwang, and Y. Hwang: "Recent Advancements in Decellularized Matrix-based Biomaterials for Musculoskeletal Tissue Regeneration" Adv Exp Med Biol: Novel Biomaterials for Regenerative Medicine, 2018, 1077, 149-162. (Link)

25. C. Ahn, Y. Kim, S. Park, Y. Hwang#, and J. Lee#: "Development of arginine-glycine-aspartate-immobilized 3D printed poly(propylene fumarate) scaffolds for cartilage tissue engineering" Journal of Biomaterials Science, Polymer Ed., 2018, 29(7-9), 917-931. (# denotes co-corresponding) (Link)

24. H. Kim, Y. Lee, Y. Kim, Y. Hwang#, and N. Hwang#: “Biomimetically reinforced polyvinyl alcohol-based hybrid scaffolds for cartilage tissue engineering” (#denotes co-corresponding authors) Polymers, 2017, 9(12), 655. (Link)

23. Y. Hwang, T. Seo, S. Hariri, C. Choi, and S. Varghese: “Matrix topographical cue-mediated myogenic differentiation of human embryonic stem cell derivatives” Polymers, 2017, 9(11), 580. (Link)

22. Y. Hwang, H. Broxymeyer, and M. Lee: “Generating autologous hematopoietic cells from human-induced pluripotent stem cells through ectopic expression of transcription factors” Curr Opin Hematol, 2017, 24(4), 283-88.60/9/1/13. (Link)

21. Y. Hwang, S. Park, and J. Lee: “Applications of Functionalized Carbon Nanotubes for the Therapy and Diagnosis of Cancer” Polymers, 2017, 9(1), 13. (Link)

20. C. Wen, H. Kang, Y. Shih, Y. Hwang, and S. Varghese:"In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells" Drug Delivery and Translational Research, 2016, 6(2), 121-31. (Link)

19. M. Nakasaki, Y. Hwang, Y. Xie, S. Kataria, R. Gund, E. Y. Hajam, R. Samuel, R. George, D. Danda, P. MJ, T. Nakamura, Z. Shen, S. Briggs, S. Varghese, and C. Jamora: “The matrix protein Fibulin-5 lies at the interface of tissue stiffness and inflammation in fibrosis” Nature Communications, 2015, 6:8574. (Link)

18. H. Kabra#, Y. Hwang#, M. Kar, and S. Varghese: “Biomimetic material-based delivery of stem cells enhances in vivo engraftment” ACS Biomaterials Science and Engineering, 2015, 1, 7-12. (# denotes joint first author) (Link)

17. H. Kim, J. Heo, Y. Hwang, S. Kwak, O. Park, H. Kim, S. Varghese, and N. Hwang: “Extracellular matrix-based Arg-Gly-Asp modified photopolymerizing hydrogels for cartilage tissue engineering” Tissue Engineering Part A, 2015, 21(3-4), 757-766. (Link)

2009 - 2014

16. H. Kang, Y-R. V. Shih, Y. Hwang, C. Wen, T. Seo, and S. Varghese: “Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells” Acta Biomaterialia, 2014, 10(12), 4961-4970. (Link)

15. H. Kang, C. Wen, Y. Hwang, Y. Shih, M. Kar, S. Seo, and S. Varghese: “Biomaterials matrix-assisted osteogenic differentiation of human embryonic stem cells” Journal of Materials Chemistry B, 2014, 2(34), 5676-5688. (Link)

14. Y. Hwang, S. Suk, T. Seo, B. Du, Y. Xie, Z. Li, and S. Varghese: “WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment” Scientific Reports, 2014, 4, 5916; DOI: 10.1038/srep05916. (Link)

13. H. Lim, Y. Hwang, M. Kar, and S. Varghese: “Smart hydrogels as functional biomimetic systems” Biomaterials Science, 2014, 2, 603-618. (Link)

12. Y-R. V. Shih, Y. Hwang, A. Phadke, H. Kang, N. Hwang, E. Caro, S. Nguyen, M. Siu, E. Theodorakis, N. Gianneschi, K. Vecchio, S. Chien, O. Lee, and S. Varghese: “Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling.” Proceedings of National Academy of Science, 2014, 111(3): 990-5. (Link)

Featured in UCSD news (January 6, 2014)
Featured in CIRM news (January 7, 2014)
Selected as Top story in Extracellular Matrix News 5.00 (January 9, 2014)

11. Y. Hwang#, S. Suk#, M. Tierney, S. Lin, B. Du, T. Seo, A. Mitchell, A. Sacco, and S. Varghese: “Directed in vitro myogenesis of human embryonic stem cells and their in vivo engraftment” PLoS One, 2013, 8(8): e72023. (# denotes joint first author) (Link)

10. A. Phadke#, Y. Hwang#, S. Kim, S. Kim, T. Yamaguchi, K. Masuda, and S. Varghese: “Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells” European Cells & Materials, 2013, 25, 114-29. (# denotes joint first author) (Link)

9. C. Chang#, Y. Hwang#, D. Brafman#, T. Hagan, C. Phung, and S. Varghese: “Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells” Biomaterials, 2013, 34(4), 912-21. (# denotes joint first author) (Link)

Selected as Top story in Extracellular Matrix News 3.44, November 8, 2012

8. Q. Nguyen, Y. Hwang, A. Chen, S. Varghese, and R. Sah: “Cartilage-like mechanical properties of poly(ethylene glycol)-diacrylate hydrogels” Biomaterials, 2012, 33(28), 6682-90. (Link)

7. C. Zhang, N. Sangaj, Y. Hwang, A. Phadke, C. Chang, and S. Varghese: “Oligo(trimethylene carbonate)-poly(ethylene glycol)- oligo(trimethylene carbonate) triblock based hydrogels for cartilage tissue engineering” Acta Biomaterialia, 2011, 7(9), 3362-3369. (Link)

6. Y. Hwang#, A. Phadke#, and S. Varghese: “Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells” Regenerative Medicine, 2011, 6(4), 505-24. (# denotes joint first author) (Link)

5. R. Ayala, C. Zhang, D. Yang, Y. Hwang, A. Aung, S. Shroff, F. Arce, R. Lal, G. Arya, and S. Varghese: “Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation” Biomaterials, 2011, 32(15), 3700-11. (Link)

4. A. Phadke, C. Zhang, Y. Hwang, K. Vecchio, and S. Varghese: “Templated mineralization of synthetic hydrogels for bone-like composite materials: Role of matrix hydrophobicity” Biomacromolecules, 2010, 11(8), 2060–68. (Link)

3. Y. Hwang, N. Sangaj, and S. Varghese: “Interconnected macroporous poly (ethylene glycol) (PEG) cryogels as a cell scaffold for cartilage tissue engineering” Tissue Engineering Part A, 2010, 16(10), 3033-41. (Link)

2. Y. Hwang, C. Zhang, and S. Varghese: “Poly (ethylene glycol) cryogels as potential cell scaffolds: Effect of polymerization conditions on cryogel microstructure and properties” Journal of Materials Chemistry, 2010, 20(2), 345-51. (Link)

Selected as Advance Articles for Highlights in Chemical Biology

1. N. Hwang, C. Zhang, Y. Hwang, S. Varghese: “Mesenchymal stem cell differentiation and roles in regenerative medicine” Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2009, 1(1), 97-106. (Link)